SynthArenav0.3.0
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  5. Syntheseus LocalRetro on ref-lin-600
Syntheseus LocalRetro
Benchmark
ref-lin-600
Total Routes
3536
Executed
December 3rd, 2025
Duration
154.2 min
Total Cost
$0.46
Acceptable Routes
Available
Target 1 of 600
Overall Metrics
Performance metrics across all targets in the benchmark. Hover over values to see 95% confidence intervals.
SolvabilityTop-1Top-2Top-3Top-4Top-5Top-10Top-20Top-50Top-100Top-500Top-1000Top-10000
67.2%5.0%6.7%8.5%10.2%10.8%13.0%13.0%13.0%13.0%13.0%13.0%13.0%

n = 600 targets

Metrics by Route Length
Performance breakdown by acceptable route length.
LengthSolvabilityTop-1Top-2Top-3Top-4Top-5Top-10Top-20Top-50Top-100Top-500Top-1000Top-10000n
279.0%17.0%21.0%22.0%24.0%25.0%29.0%29.0%29.0%29.0%29.0%29.0%29.0%100
369.0%8.0%10.0%15.0%18.0%18.0%22.0%22.0%22.0%22.0%22.0%22.0%22.0%100
473.0%3.0%6.0%8.0%11.0%12.0%13.0%13.0%13.0%13.0%13.0%13.0%13.0%100
572.0%2.0%2.0%4.0%5.0%5.0%7.0%7.0%7.0%7.0%7.0%7.0%7.0%100
662.0%0.0%1.0%2.0%3.0%4.0%6.0%6.0%6.0%6.0%6.0%6.0%6.0%100
748.0%0.0%0.0%0.0%0.0%1.0%1.0%1.0%1.0%1.0%1.0%1.0%1.0%100

Confidence intervals available on hover. Reliability indicators show LOW_N (insufficient samples) or EXTREME_P (value near boundary).

n5-00015

7 stepsLinearHas Acceptable Routes

SMILES

c1ccc(-c2cc3cc(-c4ccncn4)c(-c4ccco4)nc3[nH]2)cc1

InChiKey

GMOSJDXQORTJOO-UHFFFAOYSA-N

No predictions found for this target. The model did not generate any routes.