SynthArenav0.3.0
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  5. Syntheseus LocalRetro on ref-cnv-400
Syntheseus LocalRetro
Benchmark
ref-cnv-400
Total Routes
2670
Executed
December 3rd, 2025
Duration
104.3 min
Total Cost
$0.31
Acceptable Routes
Available
Target 1 of 400
Overall Metrics
Performance metrics across all targets in the benchmark. Hover over values to see 95% confidence intervals.
SolvabilityTop-1Top-2Top-3Top-4Top-5Top-10Top-20Top-50Top-100Top-500Top-1000Top-10000
74.8%6.0%8.0%8.8%10.8%11.3%13.3%13.3%13.3%13.3%13.3%13.3%13.3%

n = 400 targets

Metrics by Route Length
Performance breakdown by acceptable route length.
LengthSolvabilityTop-1Top-2Top-3Top-4Top-5Top-10Top-20Top-50Top-100Top-500Top-1000Top-10000n
284.0%15.0%20.0%22.0%27.0%27.0%28.0%28.0%28.0%28.0%28.0%28.0%28.0%100
384.0%7.0%8.0%8.0%11.0%12.0%14.0%14.0%14.0%14.0%14.0%14.0%14.0%100
465.0%1.0%2.0%2.0%2.0%2.0%6.0%6.0%6.0%6.0%6.0%6.0%6.0%100
566.0%1.0%2.0%3.0%3.0%4.0%5.0%5.0%5.0%5.0%5.0%5.0%5.0%100

Confidence intervals available on hover. Reliability indicators show LOW_N (insufficient samples) or EXTREME_P (value near boundary).

n5-00045

4 stepsConvergentHas Acceptable Routes

SMILES

OC(COc1cccc(-c2ccc3ncn(Cc4ccccc4)c3c2)c1)CN1CCc2ccccc2C1

InChiKey

QRPLRPXUJNDKKA-UHFFFAOYSA-N

Prediction Route
Rank 1 • Length: 3 steps • Convergent
Solved
Solvability evaluated against: n5 Stock
View:
Single route available
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Rank:
Rank 1 of 10
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Hash: 0ebb3f6632cf49d0952c175d26307e18dd1acdc35d7341d8767eb03234d631c4